I’m just beginning a build, and have no previous CNC or CAM experience, but approach the subject from a woodworking perspective. I look forward to taking my design ideas in sketch up, and arranging the router workflow, its path, feed rate, depth of cut and therefore number of passes. These variables will be different depending on materials, types of wood, card, etc, I’d imagine.
Ensure an appropriate router cutter path: avoid instances where the router could be allowed to climb-route even with a big sturdy ‘site’ router it can sometimes clip an edge and flick the router significantly. The blade kicking against the workpiece creates a jolt/backlash/kick that can lead to screw-ups and broken bits, so it definitely stresses them!
As a woodworker I’m inclined to make more passes, removing a little each time and keeping the feed rate low, this way keeping bit temperature down and hopefully improving quality of cut. Consideration should be given to grain direction of the wood, any denser knotted areas and changes in the density, many species of lumber are surprisingly variable in their density.
Keep your bits clean. Blade cleaners are available and help remove wood resins and burnt on gunk such as the glues in manufactured and engineered sheet products. Clean them regularly, really regularly if you want a better quality of cut!
Search youtube woodworking channels for specific advice on routing different products, you can whizz through clear pine, but knotted oak panels present a whole different problem!